Case 1
Partial Thickness, Plantar Forefoot Ulcer
✅ Patient History: 48-year-old male with type 2 diabetes and BMI of 26. Other medical history includes hypertension and hyperlipidemia.
✅ Challenges: Wound had been present for 79 days at the time that treatment began.
✅ Initial Assessment: He presented with a partial thickness, right plantar forefoot ulcer. The initial surface area of the wound was measured at 5.5 cm2 .
✅ Previous Treatment: Standard wound care including debridement, exudate management, and offloading.
✅ Treatment Strategy: Amnion grafts were applied weekly in addition to debridement and application of moist wound dressing. A non-adherent layer was utilized to prevent the dressings from coming into direct contact with the product or wound.
✅ Wound Progress: By week 4, the wound decreased in size to 0.28cm2 , representing an 95% area reduction.
✅ Outcome: Time to wound closure was 48 days with 6 applications of amnion grafts.
Case 2
Dehisced Onychectomy Site
✅ Patient History: 60 year old non-compliant man with poorly controlled diabetes mellitus.
✅ Challenges: Taxi driver with hypertension and HIV+.
✅ Initial Assessment: Dehiscence of onychectomy site.
✅ Previous Treatment: Self care. Treatment Strategy: Clean and debride wound and apply Amnion graft every 1-2 weeks.
✅ Wound Progress: At Day 0, wound measured 3.5 x 0.8 x 0.3 cm; Day 14: 2.0 x 0.5 x 0.2 cm.
✅ Outcome: Complete closure obtained on Day 35 following 2 applications of Amnion grafts.
Venus Leg Ulcer
Case 3
✅ Patient History: 59 year old man with a Venus Leg Ulcer (VLU) of 11 month duration.
✅ Challenges: Chronic venous insufficiency and underwent ablation about 1 year ago.
✅ Initial Assessment: VLU on Right leg.
✅ Previous Treatment: Compression and absorptive dressings.
✅ Treatment Strategy: Clean and debride wound and apply Amnion grafts.
✅ Wound Progress: At Day 0, the wound measured 1.2 x 1.0 cm and Amnion graft was applied and dressed with a 3 layer compression bandage.
On Day 12 the wound had decreased to 0.7 x 0.5 cm and Amnion graft was reapplied. Day 22, wound area had increased to 1.4 x 0.9 cm and visible hypergranulation tissue was treated with silver nitrate.
Hypergranulation tissue was again treated with silver nitrate on Day 29 visit.
By Day 35, despite persistent hypergranulation tissue, the wound area had decreased to 0.5 x 0.7 cm, and was closed three weeks later at the Day 56 visit.
✅ Outcome: Recalcitrant VLU of 11 months duration closed in 8 weeks with consistent compression dressings and 2 applications of Amnion grafts.
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